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Updated: Jun 25, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
Published on: May 3, 2018
Pulse wave velocity for assessment of arterial stiffness among people with spinal cord injury: a pilot study
Masae Miyatani1, Kei Masani, Paul I Oh
1Lyndhurst Center, Toronto Rehabilitation Institute, 520 Sutherland Drive, Toronto, Ontario, Canada M4G 3V9. miyatani.masae@torontorehab.on.ca
Insights
People with spinal cord injury (SCI) have higher aortic pulse wave velocity (PWV), indicating an increased risk of coronary artery disease (CAD). This study compared PWV in SCI and non-SCI groups, finding significantly elevated aortic PWV in the SCI cohort.
Area of Science:
- Cardiovascular research
- Neurology
- Biomedical engineering
Background:
- Coronary artery disease (CAD) is a major cause of mortality in individuals with spinal cord injury (SCI).
- Aortic pulse wave velocity (PWV) is a recognized predictor of CAD in the general population.
- No previous studies have reported PWV values specifically for individuals with SCI.
Purpose of the Study:
- To investigate and compare aortic, arm, and leg pulse wave velocity (PWV) between individuals with SCI and able-bodied controls.
- To determine if aortic PWV differs between these groups as a potential indicator of cardiovascular risk in SCI.
Main Methods:
- The study included 12 men with SCI and 9 age-, sex-, height-, and weight-matched non-SCI controls.
- Exclusion criteria included a history of CAD or current metabolic syndrome.
- Aortic, arm, and leg PWV were measured using the echo Doppler method.
Main Results:
- Aortic PWV was significantly higher in the SCI group (1,274 cm/s) compared to the non-SCI group (948 cm/s) (P < 0.05).
- No significant differences were observed in arm PWV between the SCI (1,152 cm/s) and non-SCI (1,237 cm/s) groups.
- Similarly, leg PWV did not differ significantly between the SCI (1,096 cm/s) and non-SCI (994 cm/s) groups.
Conclusions:
- Individuals with SCI exhibited higher mean aortic PWV compared to their able-bodied counterparts.
- Elevated aortic PWV in the SCI group suggests an increased risk for coronary artery disease, even without metabolic syndrome.
- Aortic PWV may serve as a valuable biomarker for assessing cardiovascular risk in the SCI population.
Background/Objective:
The most significant complication and leading cause of death for people with spinal cord injury (SCI) is coronary artery disease (CAD). It has been confirmed that aortic pulse wave velocity (PWV) is an emerging CAD predictor among able-bodied individuals. No prior study has described PWV values among people with SCI. The objective of this study was to compare aortic (the common carotid to femoral artery) PWV, arm (the brachial to radial artery) PWV, and leg (the femoral to posterior tibial artery) PWV in people with SCI (SCI group) to able-bodied controls (non-SCI group).
Methods:
Participants included 12 men with SCI and 9 non-SCI controls matched for age, sex, height, and weight. Participants with a history of CAD or current metabolic syndrome were excluded. Aortic, arm, and leg PWV was measured using the echo Doppler method.
Results:
Aortic PWV (mean +/- SD) in the SCI group (1,274 +/- 369 cm/s) was significantly higher (P < 0.05) than in the non-SCI group (948 +/- 110 cm/s). There were no significant between-group differences in mean arm PWV (SCI: 1,152 +/- 193 cm/s, non-SCI: 1,237 +/- 193 cm/s) or mean leg PWV (SCI: 1,096 +/- 173 cm/s, non-SCI: 994 +/- 178 cm/s) values.
Conclusions:
Aortic PWV was higher among the SCI group compared with the non-SCI group. The higher mean aortic PWV values among the SCI group compared with the non-SCI group indicated a higher risk of CAD among people with SCI in the absence of metabolic syndrome.
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