Pulse wave velocity for assessment of arterial stiffness among people with spinal cord injury: a pilot study

Masae Miyatani1, Kei Masani, Paul I Oh

  • 1Lyndhurst Center, Toronto Rehabilitation Institute, 520 Sutherland Drive, Toronto, Ontario, Canada M4G 3V9. miyatani.masae@torontorehab.on.ca

Insights

People with spinal cord injury (SCI) have higher aortic pulse wave velocity (PWV), indicating an increased risk of coronary artery disease (CAD). This study compared PWV in SCI and non-SCI groups, finding significantly elevated aortic PWV in the SCI cohort.

Area of Science:

  • Cardiovascular research
  • Neurology
  • Biomedical engineering

Background:

  • Coronary artery disease (CAD) is a major cause of mortality in individuals with spinal cord injury (SCI).
  • Aortic pulse wave velocity (PWV) is a recognized predictor of CAD in the general population.
  • No previous studies have reported PWV values specifically for individuals with SCI.

Purpose of the Study:

  • To investigate and compare aortic, arm, and leg pulse wave velocity (PWV) between individuals with SCI and able-bodied controls.
  • To determine if aortic PWV differs between these groups as a potential indicator of cardiovascular risk in SCI.

Main Methods:

  • The study included 12 men with SCI and 9 age-, sex-, height-, and weight-matched non-SCI controls.
  • Exclusion criteria included a history of CAD or current metabolic syndrome.
  • Aortic, arm, and leg PWV were measured using the echo Doppler method.

Main Results:

  • Aortic PWV was significantly higher in the SCI group (1,274 cm/s) compared to the non-SCI group (948 cm/s) (P < 0.05).
  • No significant differences were observed in arm PWV between the SCI (1,152 cm/s) and non-SCI (1,237 cm/s) groups.
  • Similarly, leg PWV did not differ significantly between the SCI (1,096 cm/s) and non-SCI (994 cm/s) groups.

Conclusions:

  • Individuals with SCI exhibited higher mean aortic PWV compared to their able-bodied counterparts.
  • Elevated aortic PWV in the SCI group suggests an increased risk for coronary artery disease, even without metabolic syndrome.
  • Aortic PWV may serve as a valuable biomarker for assessing cardiovascular risk in the SCI population.
Abstract

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