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Updated: Jun 25, 2026

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors
Published on: November 14, 2014
Engineered toxins: new therapeutics
1Syntaxin Ltd., Units 4-10, The Quadrant Barton Lane, Abingdon, Oxon, OX14 3YS, UK. keith.foster@syntaxin.com
Abstract:
Clostridial neurotoxins possess discrete structural domains with distinct pharmacological properties. Aspects of neurotoxin function with therapeutic potential include specific neuronal binding, intracellular (cytosolic) delivery of biologically active protein and inhibition of SNARE-mediated secretion. Understanding the structure function relationship of the neurotoxin protein enables the creation of recombinant proteins incorporating select domains of the neurotoxins to produce novel proteins with therapeutic potential in a range of clinical applications.
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