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Updated: Jun 25, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates
Published on: November 23, 2016
Diacylglycerol kinases as sources of phosphatidic acid
Jinjin Cai1, Hanan Abramovici, Stephen H Gee
1Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA.
Abstract:
There are ten mammalian diacylglycerol kinases (DGKs) whose primary role is to terminate diacylglycerol (DAG) signaling. However, it is becoming increasingly apparent that DGKs also influence signaling events through their product, phosphatidic acid (PA). They do so in some cases by associating with proteins and then modifying their activity by generating PA. In other cases, DGKs broadly regulate signaling events by virtue of their ability to provide PA for the synthesis of phosphatidylinositols (PtdIns).
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