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Cardiac troponin-I and risk of heart failure: a community-based cohort study

Johan Sundström1, Erik Ingelsson, Lars Berglund

  • 1Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden. johan.sundstrom@medsci.uu.se

European Heart Journal
|March 7, 2009
PubMed

Insights

Elevated cardiac troponin-I (cTnI) levels in apparently healthy older men predict future heart failure risk. Measuring cTnI may help identify individuals who could benefit from early intervention.

Area of Science:

  • Cardiology
  • Biomarkers
  • Preventive Medicine

Background:

  • Heart failure is a major cause of morbidity and mortality.
  • Early identification of individuals at risk is crucial for timely intervention.
  • Cardiac troponin-I (cTnI) is a marker of cardiomyocyte damage.

Purpose of the Study:

  • To investigate whether circulating cardiac troponin-I (cTnI) levels predict the risk of developing heart failure in a community-based sample of older men.
  • To assess the association between cTnI levels and subsequent heart failure hospitalizations, independent of other cardiovascular risk factors.

Main Methods:

  • A community-based cohort of 1089 70-year-old men without pre-existing heart failure was studied.
  • Cox proportional hazards models were used to analyze the risk of first heart failure hospitalization over a median follow-up of 11.4 years.
  • Analyses adjusted for traditional cardiovascular risk factors including smoking, blood pressure, diabetes, and cholesterol.

Main Results:

  • Higher circulating cTnI levels were significantly associated with an increased risk of subsequent heart failure.
  • Each 0.01 microg/L increase in cTnI conferred a 26% higher hazard ratio for heart failure (HR 1.26).
  • Men with cTnI levels >= 0.03 microg/L had a 5.25-fold increased risk of heart failure compared to those with cTnI < 0.01 microg/L.

Conclusions:

  • Circulating cTnI is a significant predictor of heart failure in community-dwelling older men, even after accounting for other risk factors.
  • These findings suggest that cTnI may serve as a valuable biomarker for identifying individuals at high risk for heart failure.
  • Further research is warranted to explore the clinical utility of cTnI measurements in asymptomatic populations for heart failure risk stratification.
Abstract

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