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Updated: Jun 25, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Mediastinal large B-cell lymphoma associated with systemic sclerosis].
Honoka Arai1, Hisako Iso, Yukihiro Arai
1Department of Hematology, Dokkyo Medical University School of Medicine, Japan.
Summary
Systemic sclerosis (SSc) patients rarely develop malignant lymphoma (ML). This case report details the first instance of SSc associated with mediastinal large B-cell lymphoma (MLBCL), highlighting the need for vigilant ML monitoring in SSc patients.
Area of Science:
- Oncology
- Rheumatology
- Pathology
Background:
- Malignant lymphoma (ML) is linked to collagen diseases like Sjogren syndrome and rheumatoid arthritis.
- ML occurrence in systemic sclerosis (SSc) is exceptionally rare.
Observation:
- A 31-year-old female SSc patient developed a mediastinal tumor one year post-diagnosis.
- Pathohistological and immunohistochemical analyses confirmed mediastinal (thymic) large B-cell lymphoma (MLBCL).
Findings:
- This is the first reported case of SSc associated with MLBCL.
- The patient achieved complete remission after CHOP chemotherapy for the lymphoma.
Implications:
- SSc patients may develop ML after a short interval.
- Intensive monitoring for ML is crucial for newly diagnosed SSc patients.
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