Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Staging models applied in a sample of patients with bipolar disorder: Results from a retrospective cohort study.

Journal of affective disorders·2022
Same author

Expert consensus recommendations on the use of randomized clinical trials for drug approval in psychiatry- comparing trial designs.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2022
Same author

Childhood trauma and treatment outcomes during mood-stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder.

Acta psychiatrica Scandinavica·2022
Same author

Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes.

The Australian and New Zealand journal of psychiatry·2022
Same author

Cardiometabolic risk markers during mood-stabilizing treatment: Correlation with drug-specific effects, depressive symptoms and treatment response.

Journal of affective disorders·2021
Same author

Response and remission rates during 24 weeks of mood-stabilizing treatment for bipolar depression depending on early non-response.

Psychiatry research·2021

Related Experiment Videos

Treating bipolar disorder: monotherapy versus combination therapy.

Terence A Ketter1

  • 1Department of Psychiatry and Behavior Sciences and the Bipolar Disorders Clinic, Stanford University School of Medicine, Stanford, CA, USA.

The Journal of Clinical Psychiatry
|March 7, 2009
PubMed
Summary

Combining treatments for bipolar disorder may offer benefits but carries risks of drug interactions and side effects. Careful evaluation of efficacy, tolerability, and safety is crucial for individual patients.

Related Experiment Videos

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Medicine

Background:

  • Bipolar disorder management often involves pharmacotherapy.
  • Combination treatments can enhance therapeutic effects through synergy.
  • Potential for increased drug interactions and adverse events exists with combined therapies.

Purpose of the Study:

  • To review the advantages and disadvantages of combination treatments for bipolar disorder.
  • To emphasize the importance of individualized patient assessment for combination therapy.
  • To guide clinical decision-making regarding pharmacotherapy for bipolar disorder.

Main Methods:

  • Literature review of studies on combination pharmacotherapy in bipolar disorder.
  • Analysis of efficacy, tolerability, and safety data for combined drug regimens.
  • Clinical guidelines and expert opinion synthesis.

Main Results:

  • Therapeutic synergy can improve outcomes in some bipolar disorder patients.
  • Increased risk of adverse drug reactions and interactions necessitates careful monitoring.
  • Individual patient factors significantly influence the risk-benefit ratio of combination therapy.

Conclusions:

  • Combination therapy for bipolar disorder requires cautious clinical judgment.
  • Prioritize monotherapy when clinically feasible and effective.
  • Individualized assessment of efficacy, tolerability, and safety is paramount before initiating combination treatments.