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Updated: Jun 25, 2026

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
Published on: January 7, 2014
The side story of stem-like glioma cells
Anders I Persson1, William A Weiss
1Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. anders.persson@ucsf.edu
Abstract:
In this issue of Cell Stem Stell, Bleau et al. report that activity of the drug transporter ABCG2 defines a tumorigenic stem-like side population (SP) isolated from glioma. Surprisingly, temozolomide, the first-line chemotherapeutic used for treatment of glioma, increased this side population, and even more so when PTEN was deleted.
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