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Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods
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Human neuroserpin: structure and time-dependent inhibition

Stefano Ricagno1, Sonia Caccia, Graziella Sorrentino

  • 1Department of Biomolecular Sciences and Biotechnology, CNR-INFM and CIMAINA, University of Milano, Via Celoria 26, 20133 Milan, Italy.

Journal of Molecular Biology
|March 7, 2009
PubMed
Summary

Structural insights into human neuroserpin (hNS) reveal its reactive center loop and potential stabilization sites. The study highlights the unstable complex formed between hNS and tissue plasminogen activator (tPA), offering clues for neurodegenerative disease research.

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