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Updated: Jun 25, 2026
04:53
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
[Vitamins stability in parenteral nutrition].
A Such Díaz1, C Sánchez Gil, P Gomis Muñoz
1Servicio de Farmacia, Hospital Universitario 12 de Octubre, Madrid, España. anasuch@gmail.com
Nutricion Hospitalaria
|March 7, 2009
Summary
Vitamins and trace elements can be combined and administered with parenteral nutrition (PN) if using photo-protected bags and sulfite-free amino acids. This ensures stability under current preparation and administration methods.
Area of Science:
- Nutritional biochemistry
- Parenteral nutrition stability
- Vitamin and trace element interactions
Context:
- Historical practices recommend alternating vitamin and oligoelement administration due to degradation concerns.
- Current parenteral nutrition (PN) products, containers, and administration methods differ from those used when these recommendations were established.
- This review addresses the outdated practices in many Spanish hospitals regarding PN preparation.
Purpose:
- To evaluate the current recommendations for combined vitamin and oligoelement administration with PN.
- To determine the stability of vitamins and oligoelements in PN under current refrigerated storage conditions.
- To assess the compatibility of vitamins and oligoelements when administered together in PN.
Summary:
- Vitamin A degradation is reduced with 'all-in-one' administration and photo-protection.
- Vitamin E remains stable for 3-7 days refrigerated plus one day at room temperature in multilayered bags with photo-protection.
- Thiamine stability is maintained when using amino acid solutions free of bisulfites.
Impact:
- Combined administration of vitamins and oligoelements with PN is feasible and recommended under specific conditions.
- Utilizing 'all-in-one', photo-protected, multilayered bags and bisulfite-free amino acid solutions allows for pre-preparation of PN.
- These findings support updated guidelines for PN preparation, optimizing nutrient delivery and stability.
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