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Adherence to HAART: processes explaining adherence behavior in acceptors and non-acceptors
Sigrid C J M Vervoort1, Mieke H F Grypdonck, Annelies de Grauwe
1Department of Internal Medicine & Infectious Diseases, University Medical Centre, Utrecht, The Netherlands. s.vervoort@umcutrecht.nl
AIDS Care
|March 7, 2009
Summary
Patient acceptance of HIV significantly impacts adherence to highly active antiretroviral therapy (HAART). A positive stance fosters commitment, while prioritizing other life aspects can hinder medication adherence.
Area of Science:
- Medical Sociology
- HIV/AIDS Research
- Behavioral Science
Background:
- Non-adherence to highly active antiretroviral therapy (HAART) is a significant challenge in HIV management.
- Understanding the patient experience is crucial for developing effective adherence strategies.
Purpose of the Study:
- To explore and clarify the underlying processes influencing adherence behavior in patients on HAART.
- To identify key patient-driven factors affecting medication adherence.
Main Methods:
- Qualitative study employing 37 in-depth interviews with 30 Caucasian HIV-positive patients.
- Participant diaries were used for supplementary data collection.
- Cyclic thematic analysis was conducted, alternating theme selection with new data input.
Main Results:
- Patient acceptance of their HIV status is the primary determinant of HAART adherence.
- Two core stances emerged: 'determined to be adherent' versus 'medication subordinate to other priorities'.
- Themes such as 'start of HAART', 'attitude toward medication', and 'daily life integration' significantly influence adherence.
Conclusions:
- Interventions should prioritize helping patients accept HIV before initiating HAART.
- Adherence-promoting strategies must acknowledge and address patients' life priorities and coping mechanisms.
- A patient-centered approach, focusing on HIV acceptance, is vital for improving HAART adherence.
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