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Prevention of propofol pain: a comparative study
Nitin Sethi1, Lakshmi Jayaraman, Mamta Sethi
1Department of Anaesthesiology, Pain & Perioperative Medicine, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India. nitinsethi77@yahoo.co.in
Middle East Journal of Anaesthesiology
|March 10, 2009
Summary
Adding lignocaine to propofol significantly reduces injection pain. Both medium/long-chain triglyceride (MCT/LCT) and long-chain triglyceride (LCT) propofol emulsions with lignocaine are effective, showing no significant difference between them.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Pain on injection is a common adverse effect of propofol anesthesia.
- Lignocaine is frequently co-administered with propofol to mitigate this pain.
Purpose of the Study:
- To compare the efficacy of propofol medium/long-chain triglyceride (MCT/LCT) emulsion alone versus propofol MCT/LCT or propofol long-chain triglyceride (LCT) emulsion premixed with lignocaine in reducing injection pain.
Main Methods:
- 300 patients were randomized into three groups.
- Group A: propofol MCT/LCT with saline.
- Group B: propofol MCT/LCT with 20 mg lignocaine.
- Group C: propofol LCT with 20 mg lignocaine.
Main Results:
- Injection pain incidence was 63% in Group A, 15% in Group B, and 24% in Group C.
- Lignocaine significantly reduced pain in both MCT/LCT and LCT propofol emulsions compared to saline (p < 0.001).
- No significant difference in pain incidence was observed between propofol MCT/LCT and LCT when premixed with lignocaine (p = 0.11).
Conclusions:
- Propofol MCT/LCT emulsion alone does not reduce injection pain compared to lignocaine-premixed formulations.
- Both propofol MCT/LCT and LCT emulsions demonstrate comparable efficacy in pain reduction when combined with lignocaine.
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