Related Experiment Video
Updated: Jun 25, 2026

Non-Intubated Video-Assisted Thoracoscopic Surgery
Published on: May 26, 2023
Low dose intravenous midazolam for prevention of PONV, in lower abdominal surgery--preoperative vs intraoperative
Mohammad Reza Safavi1, Azim Honarmand
1Department of Anesthesiology and Intensive Care Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. safavi@med.mui.ac.ir
Background:
The aim of the present study was to compare anti-emetic efficacy of low dose midazolam premedication (35 microg/kg) 15 minutes before induction of anesthesia with midazolam (35 microg/kg) administered intravenously 30 min before conclusion of surgery, in patients undergoing lower abdominal surgery under general anesthesia.
Methods:
Sixty patients were assigned to one of three equal groups: Group MP (n = 20), which received intravenous midazolam 35 microg/kg in a volume of 3 ml 15 minutes before induction of anesthesia and 3 ml normal saline 30 minutes before extubation. Group MI (n = 20), which received 3 ml normal saline 15 minutes before induction of anesthesia and intravenous midazolam 35 microg/kg in a volume of 3 ml 30 minutes before extubation. Group NS (n = 20), which received 3 ml normal saline 15 minutes before induction of anesthesia plus 3 ml normal saline 30 minutes before extubation. Assessments of the occurrence of postoperative nausea and vomiting (PONV) were made at regular intervals for the first 24 h.
Results:
Incidence of PONV was significantly lower in Group MI compared with Group NS and Group MP at 6, 12, 18, and 24 hours after operation (P < 0.05). The time for the first episode of PONV was significantly higher in Group MI compared with Group NS and Group MP (P < 0.05).
Conclusion:
Our results indicated that midazolam 35 microg/kg (2 mg) given intravenously 30 minutes before the end of surgery was more effective in decreasing the incidence of PONV than midazolam premedication 35 microg/kg.
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