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Related Concept Videos

Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
Distribution and Dispersion00:54

Distribution and Dispersion

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Related Experiment Video

Updated: Jun 25, 2026

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology
09:55

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Published on: September 28, 2022

Start spreading the news.

Felicia Cox

    Journal of Perioperative Practice
    |March 10, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Hematopoietic stem cells, found in bone marrow, can be stimulated to enter the bloodstream. These circulating stem cells can then be collected for transplantation into recipients.

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    Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology
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    Published on: September 28, 2022

    Propagation of Human Embryonic Stem (ES) Cells
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    Chromosomal Spread Preparation of Human Embryonic Stem Cells for Karyotyping
    10:42

    Chromosomal Spread Preparation of Human Embryonic Stem Cells for Karyotyping

    Published on: September 4, 2009

    Area of Science:

    • Hematology
    • Stem Cell Biology
    • Regenerative Medicine

    Background:

    • Hematopoietic stem cells (HSCs) are multipotent progenitor cells residing in the bone marrow.
    • HSCs differentiate into all mature blood cell types, including erythrocytes, leukocytes, and thrombocytes.
    • Their primitive, undifferentiated nature makes them crucial for maintaining lifelong hematopoiesis.

    Discussion:

    • Growth factors, such as Granulocyte Colony-Stimulating Factor (GCSF), can mobilize HSCs from the bone marrow into peripheral circulation.
    • This mobilization strategy allows for the collection of HSCs without invasive bone marrow harvesting.
    • Peripheral blood stem cell collection is a cornerstone of modern stem cell transplantation.

    Key Insights:

    • Bone marrow stimulation with factors like GCSF effectively increases circulating stem cell numbers.
    • Blood cell separators efficiently isolate HSCs from peripheral blood.
    • Mobilized peripheral blood stem cells are a viable alternative to bone marrow stem cells for transplantation.

    Outlook:

    • Further research into novel stimulating factors could enhance stem cell mobilization efficiency.
    • Optimizing apheresis techniques may improve stem cell yield and purity.
    • Expanded applications of mobilized stem cells in various therapeutic areas are anticipated.