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Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis
Payaningal R Somanath1, Nikolay L Malinin, Tatiana V Byzova
1Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Angiogenesis
|March 10, 2009
Summary
The interaction between vascular endothelial growth factor receptor 2 (VEGFR2) and integrin alphavbeta3 on endothelial cells is vital for blood vessel formation. This cross-talk enhances cell migration, survival, and tube development during angiogenesis.
Area of Science:
- Cell biology
- Molecular biology
- Angiogenesis research
Background:
- Receptor tyrosine kinases and integrin receptors engage in crucial cross-talk for cellular functions.
- The interaction between integrin alphavbeta3 and VEGFR2 is particularly significant in endothelial cells during vascularization.
Purpose of the Study:
- To discuss mechanisms mediating the complex formation between VEGFR2 and alphavbeta3 on endothelial cells.
- To present pathological consequences and regulatory events of this receptor cross-talk.
Main Methods:
- Literature review of studies investigating VEGFR2-integrin alphavbeta3 interactions.
- Analysis of proposed molecular mechanisms for complex formation.
- Review of pathological implications and regulatory pathways.
Main Results:
- The association between VEGFR2 and integrin alphavbeta3 is reciprocal, with each receptor activating the other.
- This interaction is essential for endothelial cell migration, survival, and tube formation.
- The cross-talk also influences hematopoietic cell functions within the vasculature.
Conclusions:
- The cross-talk between VEGFR2 and integrin alphavbeta3 is a key regulator of angiogenesis.
- Understanding the mechanisms and regulation of this interaction is important for addressing pathological conditions related to vascularization.
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