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Related Experiment Video

Updated: Jun 25, 2026

Infinium Assay for Large-scale SNP Genotyping Applications

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

GMFilter and SXTestPlate: software tools for improving the SNPlex genotyping system.

Markus Teuber¹, Michael H Wenz, Stefan Schreiber

¹Institute for Clinical Molecular Biology, Christian-Albrechts-University Kiel, Arnold-Heller-Str, 3, D-24105 Kiel, Germany. m.teuber@mucosa.de

BMC Bioinformatics

|March 10, 2009

Summary

New software tools, GMFilter and SXTestPlate, enhance quality control for SNPlex genotyping. These programs automate data processing and genotype concordance checks, improving SNP analysis in high-throughput labs.

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Area of Science:

Genetics
Bioinformatics

Background:

Single-nucleotide polymorphism (SNP) genotyping is crucial in modern genetics.
The SNPlex system allows simultaneous genotyping of up to 48 SNPs per DNA sample.
High-throughput labs require advanced software for quality control and workflow management.

Purpose of the Study:

To develop software tools for quality control in SNPlex genotyping.
To automate data processing and genotype analysis for SNPlex data.
To provide reliable quality control for SNPlex genotyping platforms.

Main Methods:

Development of two software programs: GMFilter and SXTestPlate.
GMFilter automatically removes low-signal wells from SNPlex plates.
SXTestPlate assesses genotype concordance using control SNP sets for quality checks.

Main Results:

GMFilter standardizes raw data processing before GeneMapper analysis.
SXTestPlate enables regular quality control of SNPlex platforms.
Both programs are compatible with other genotyping methods.

Conclusions:

GMFilter and SXTestPlate offer valuable tools for SNPlex genotyping laboratories.
These programs improve SNPlex plate analysis and GeneMapper software integration.
The tools aid scientists in evaluating genotyping platform performance.