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Oral lichen planus and dermal dendrocytes
A L Cardozo1, C Moura-Castro, M Figueiredo
1Sector of Dermatology and Post Graduation Course, HUCFF/UFRJ and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Actas Dermo-Sifiliograficas
|March 10, 2009
Summary
Dermal dendrocytes (DD) are present in oral lichen planus (OLP), with factor XIIIa+ DD found in superficial layers and CD34+ DD in deeper tissues, suggesting their role in OLP pathogenesis.
Area of Science:
- Oral pathology
- Immunohistochemistry
- Dermatology
Background:
- Oral lichen planus (OLP) is a common inflammatory condition with unclear pathogenesis.
- Lymphocytes, cytokines, and dermal dendrocytes (DD) are implicated in OLP.
- Two types of DD, factor XIIIa+ (type I) and CD34+ (type II), are involved.
Purpose of the Study:
- To investigate the presence and distribution of factor XIIIa+ and CD34+ DD in OLP.
- To correlate DD presence with OLP clinical and histopathological features.
Main Methods:
- Immunohistochemistry was used to analyze 23 OLP tissue specimens.
- Tissue distribution of factor XIIIa+ DD and CD34+ DD was assessed.
Main Results:
- Factor XIIIa+ DD were predominantly in the superficial dermis and dermal-epidermal junction, near lymphocytes.
- CD34+ DD were mainly located in the deep dermis, below lymphocyte infiltrates.
- Both DD types were observed in the epithelium and submucosa.
Conclusions:
- Dermal dendrocytes (DD) are present in OLP with distinct tissue distributions.
- Factor XIIIa+ DD are concentrated superficially, while CD34+ DD are found deeper.
- Factor XIIIa+ DD may play a significant role in OLP pathogenesis due to their expression of ICAM-1 and TNF-alpha.
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