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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Animal Models of Depression - Chronic Despair Model (CDM)
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Published on: September 23, 2021

[Depression and circadian rhythm].

J M Azorin1, A Kaladjian

  • 1Hôpital Sainte Marguerite, Service de Psychiatrie Adulte, 270, Bld Sainte Marguerite, 13274 Marseille cedex 9. jazorin@mail.ap-hm.fr

L'Encephale
|March 10, 2009
PubMed
Summary
This summary is machine-generated.

Circadian rhythm disruptions are key features of depression, impacting hormonal rhythms. Research explores models and therapies like phototherapy to address these biological and psychological changes, though causality remains unclear.

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Area of Science:

  • Chronobiology
  • Psychiatry
  • Neuroscience

Context:

  • Circadian rhythm abnormalities are central to endogenous and seasonal depression.
  • These disruptions manifest in hormonal secretory rhythms, including amplitude, fluctuations, and periodicity.
  • Depression involves psychometric, physiological, and biological alterations linked to internal clock disturbances.

Purpose:

  • To review pathophysiological and psychopathological models of circadian rhythm disturbances in depression.
  • To explore therapeutic strategies derived from these models.
  • To address the unresolved question of causality between circadian changes and depressive behavior.

Summary:

  • Classical adverse changes involve hormonal rhythm modifications (amplitude, fluctuations, periodicity).
  • Leading models include free-running, phase advance, hypnic, and internal clock disturbance models.
  • Psychopathological models encompass endokinesis and psychosocial desynchronization.
  • Therapeutic interventions involve wake-sleep cycle manipulation, phototherapy, melatonin, time-space management, and resynchronization capacity development.

Impact:

  • Provides a framework for understanding the complex relationship between circadian rhythms and depression.
  • Highlights diverse therapeutic avenues targeting chronobiological dysregulation.
  • Underscores the need for further research into the causal role of circadian changes in depression.