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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

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Related Experiment Video

Updated: Jun 25, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

[Schizophrenia and circadian rhythms].

J-M Vanelle1

  • 1Hôpital Saint-Jacques, 85, rue Saint-Jacques, 44093 Nantes cedex. Jean-Marie.Vanelle@chu-nantes.fr

L'Encephale
|March 10, 2009
PubMed
Summary
This summary is machine-generated.

Schizophrenia patients show altered circadian rhythms, particularly in sleep patterns. Further research is needed to confirm if antipsychotics can resynchronize sleep disturbances in schizophrenia.

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Related Experiment Videos

Last Updated: Jun 25, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
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Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Area of Science:

  • Neuroscience
  • Chronobiology
  • Psychiatry

Context:

  • Circadian rhythm research in schizophrenia is limited, with existing data primarily on sleep-wake cycles and outdated.
  • Clinical observations in schizophrenia often note reduced sleep time and increased sleep fragmentation, particularly during psychotic episodes.
  • Previous hypotheses, like 'intermediate sleep,' remain underexplored in the context of schizophrenic sleep patterns.

Purpose:

  • To review and synthesize current knowledge on circadian rhythm disturbances in patients with schizophrenia.
  • To highlight methodological challenges hindering comprehensive circadian rhythm studies in this population.
  • To discuss potential implications of sleep abnormalities as markers of the schizophrenic illness state.

Summary:

  • Limited studies on circadian rhythms in schizophrenia exist, often focusing on basic sleep-wake patterns.
  • EEG findings suggest potential abnormalities, including increased MOR density and reduced REM latency during delusional phases.
  • Sleep reduction is considered a potential marker for the schizophrenic disease state, rather than a specific symptom.

Impact:

  • Suggests a potential role for antipsychotic medications in resynchronizing sleep patterns, though this requires further investigation.
  • Underscores the need for more rigorous research into circadian rhythm disruptions in schizophrenia.
  • Highlights sleep fragmentation as a potential therapeutic target or biomarker in schizophrenia management.