Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autocrine growth factors and solid tumor malignancy.

J H Walsh1, W E Karnes, F Cuttitta

  • 1CURE/Wadsworth Department of Veterans Affairs, Los Angeles, CA 90073.

The Western Journal of Medicine
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rotator cuff outcomes and mental health indices: Correlation or causation?

Shoulder & elbow·2023
Same author

The analgesic effect of transversalis fascia plane block after caesarean section under spinal anaesthesia with intrathecal morphine: a randomised controlled trial.

Anaesthesia·2023
Same author

Healthcare use attributable to COVID-19: a propensity-matched national electronic health records cohort study of 249,390 people in Wales, UK.

BMC medicine·2023
Same author

'Vancowax' for haemostasis and topical antibiotic post sternotomy.

Annals of the Royal College of Surgeons of England·2022
Same author

Counting on U training to enhance trusting relationships and mental health literacy among business advisors: protocol for a randomised controlled trial.

BMC psychiatry·2022
Same author

Interstitial Granulomatous Drug Reaction to Ustekinumab.

Case reports in dermatological medicine·2022

Malignant cells evade growth controls, often using oncogenes and autocrine growth factors. Tumors relying on these autocrine circuits may be treatable with targeted therapies that block these essential growth signals.

Area of Science:

  • Cancer Cell Biology
  • Molecular Oncology
  • Tumorigenesis

Background:

  • Malignant cells exhibit uncontrolled growth and differentiation, a key area in cancer research.
  • Oncogene protein products are implicated in activating cellular growth signaling pathways.
  • Cancer cells can self-regulate growth via autocrine growth modulatory substances.

Purpose of the Study:

  • To investigate the role of autocrine growth factors in malignant cell proliferation.
  • To explore the therapeutic vulnerability of tumors dependent on autocrine growth circuits.

Main Methods:

  • Analysis of oncogene function in cancer cell biology.
  • Identification of autocrine growth modulatory substances released by malignant cells.
  • Characterization of autocrine growth circuits in human solid tissue malignancies.

Related Experiment Videos

Main Results:

  • Malignant cells escape normal growth constraints, involving oncogenes.
  • Autocrine growth factor loops are essential for the proliferation of certain cancer types.
  • Tumors dependent on autocrine circuits present potential therapeutic targets.

Conclusions:

  • Understanding autocrine growth factor dependency offers novel therapeutic strategies for cancer.
  • Targeting autocrine circuits with receptor antagonists or antibodies shows promise for treating specific solid tumors.
  • Emerging data highlight the significance of autocrine factors in human malignancies.