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Expression of nestin mRNA is a differentiation marker in thyroid tumors

Hiroya Yamada1, Toru Takano, Yasuhiro Ito

  • 1Department of Laboratory Medicine, Osaka University Medical School, 2-2 D2, Yamadaoka, Suita, Osaka 565-0871, Japan.

Cancer Letters
|March 10, 2009
PubMed

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...