Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Peptide Bonds02:43

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SURMOUNT-REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity.

Obesity (Silver Spring, Md.)·2026
Same author

Post hoc analysis of SURMOUNT-J: tirzepatide versus placebo and predicted 10-year cardiovascular disease risk in Japanese adults with obesity disease.

Current medical research and opinion·2026
Same author

Supporting Weight Management for Kidney Transplant Candidates in People With Obesity on Haemodialysis: The First National Survey of UK Kidney Healthcare Providers.

Diabetes, obesity & metabolism·2026
Same author

Semaglutide versus placebo in individuals with poor weight loss after bariatric surgery: a double-blinded, randomized, placebo-controlled trial.

Nature medicine·2026
Same author

Patient and clinician perspectives on the management of obesity in kidney failure prior to kidney transplantation: a mixed-methods systematic review.

EClinicalMedicine·2026
Same author

Reply to Ludwig, D. S. et al.; Robinson, E. & Forde, C. G.; Wang, Z. & Peng, C.

Nature medicine·2026

Related Experiment Video

Updated: Jun 25, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
11:36

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Peptide YY: food for thought.

Marianne T Neary1, Rachel L Batterham

  • 1Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Building, London, United Kingdom.

Physiology & Behavior
|March 10, 2009
PubMed
Summary

The gut hormone peptide YY 3-36 (PYY3-36) shows promise for obesity treatment. Studies indicate PYY3-36 can reduce body fat and appetite, offering potential for weight management strategies.

Area of Science:

  • Endocrinology
  • Metabolism
  • Obesity Research

Background:

  • Rising global obesity rates necessitate understanding appetite regulation.
  • Gut hormones play a crucial role in energy homeostasis.
  • Peptide YY 3-36 (PYY3-36) has emerged as a key player in appetite control.

Purpose of the Study:

  • To investigate the role of PYY3-36 in appetite regulation and energy balance.
  • To evaluate the therapeutic potential of PYY3-36 for obesity treatment.

Main Methods:

  • Analysis of circulating PYY concentrations in relation to BMI and waist circumference.
  • Assessment of PYY3-36 effects in diet-induced obese rodent models.
  • Studies on Pyy null mice to determine the impact of PYY deficiency.

More Related Videos

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
08:01

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells
12:38

Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells

Published on: November 6, 2021

Related Experiment Videos

Last Updated: Jun 25, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
11:36

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
08:01

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells
12:38

Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells

Published on: November 6, 2021

Main Results:

  • Fasting PYY levels negatively correlate with BMI and waist circumference.
  • Postprandial PYY levels predict long-term weight changes.
  • Pyy null mice exhibit hyperphagia and increased adiposity, reversed by PYY3-36 administration.
  • Chronic PYY3-36 treatment in obese rodents reduced adiposity dose-dependently.

Conclusions:

  • The PYY system is a significant mediator of appetite and energy homeostasis.
  • PYY3-36 demonstrates potent anorectic effects and anti-obesity properties.
  • Targeting the PYY system holds substantial potential for novel obesity therapies.