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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Related Experiment Video

Updated: Jun 25, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

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Peripheral tolerance in CD8+ T cells.

Mathangi Srinivasan1, Kenneth A Frauwirth

  • 1Department of Cell Biology and Molecular Genetics, University of Maryland, Bldg. 231 Room 2113, College Park, MD 20742, USA.

Cytokine
|March 10, 2009
PubMed
Summary

Peripheral tolerance mechanisms are crucial for immune homeostasis, especially for CD8(+) T cells. This review explores how CD8(+) T cells maintain tolerance to self-antigens and foreign antigens in the periphery.

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • Immune homeostasis relies on T cell tolerance to self- and foreign antigens.
  • Thymic deletion of self-reactive T cells is incomplete, necessitating peripheral tolerance mechanisms.
  • CD8(+) T cells require peripheral tolerance due to their widespread antigen encounter and lack of costimulation requirement for cytotoxic function.

Purpose of the Study:

  • To review the modes of peripheral tolerance in CD8(+) T cells.
  • To examine antigen and signaling requirements for CD8(+) T cell tolerance induction and maintenance.
  • To compare CD8(+) and CD4(+) T cell tolerance mechanisms.

Main Methods:

  • Literature review of existing research on T cell tolerance.
  • Analysis of antigen presentation and signaling pathways involved in tolerance.

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  • Comparative analysis of CD8(+) and CD4(+) T cell tolerance.

    • Main Results:

    • Peripheral tolerance mechanisms are essential for controlling CD8(+) T cell responses.
    • Both naive and effector CD8(+) T cells employ distinct tolerance strategies.
    • Antigen affinity and specific signaling pathways critically influence tolerance induction and maintenance.

    Conclusions:

    • Peripheral tolerance is vital for preventing autoimmunity and maintaining immune homeostasis in CD8(+) T cells.
    • Understanding CD8(+) T cell tolerance mechanisms can inform strategies for managing immune responses.
    • Further research is needed to fully elucidate the nuances of CD8(+) vs. CD4(+) T cell tolerance.