Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Sympathetic Activation01:16

Sympathetic Activation

The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

Overview
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Sympathetic Division of the ANS01:19

Sympathetic Division of the ANS

The sympathetic division of the autonomic nervous system (ANS) plays a crucial role in preparing the body for stress, physical activity, and increased energy demands. This division activates the "fight-or-flight" response, enabling individuals to respond effectively to challenging situations.
Originating in the thoracic and lumbar spinal cord segments, the preganglionic fibers of the sympathetic division exit the spinal cord through the white ramus communicans. They then enter the sympathetic...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autonomic nervous system influences on beat-to-beat blood pressure variability in healthy young adults.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Multi-modal magnetic resonance imaging to assess cerebrovascular function in patients with atrial fibrillation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Combined androgen excess polycystic ovary syndrome and obesity are associated with elevated beat-to-beat blood pressure variability in adult women.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Slow deep breathing reduces muscle sympathetic nerve activity and improves breathing efficiency in pulmonary hypertension.

ERJ open research·2026
Same author

A qualitative exploration of the perceptions of music use by healthcare professionals in the operating theatre (the BACH study).

Scientific reports·2026
Same author

Sex differences in the peripheral determinants of oxygen transport and utilization in patients with heart failure with preserved ejection fraction.

American journal of physiology. Heart and circulatory physiology·2026

Related Experiment Video

Updated: Jun 25, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Central sympathetic overactivity: maladies and mechanisms.

James P Fisher1, Colin N Young, Paul J Fadel

  • 1School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, England, UK. j.p.fisher@bham.ac.uk

Autonomic Neuroscience : Basic & Clinical
|March 10, 2009
PubMed
Summary

Chronic sympathetic nerve overactivity is linked to disease. This review explores its pathological effects, the role of nitric oxide in neural dysregulation, and new therapeutic strategies targeting central sympathetic pathways.

More Related Videos

Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions
10:24

Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions

Published on: May 24, 2020

Surgical Lumbar Sympathectomy in Mice
05:24

Surgical Lumbar Sympathectomy in Mice

Published on: July 5, 2024

Related Experiment Videos

Last Updated: Jun 25, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions
10:24

Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions

Published on: May 24, 2020

Surgical Lumbar Sympathectomy in Mice
05:24

Surgical Lumbar Sympathectomy in Mice

Published on: July 5, 2024

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Pathophysiology

Background:

  • Many diseases are associated with sustained increases in sympathetic nerve activity.
  • Central sympathetic overactivity is a key factor in disease pathogenesis.

Purpose of the Study:

  • To review the pathological consequences of excessive sympathetic nerve activity.
  • To examine the role of central nitric oxide in neural dysregulation.
  • To discuss novel therapeutic strategies for central sympathetic overactivity.

Main Methods:

  • Literature review integrating findings from animal and human studies.
  • Focus on central mechanisms of sympathetic overactivity.
  • Analysis of the role of nitric oxide in neural pathways.

Main Results:

  • Sympathetic overactivity contributes significantly to disease pathology.
  • Central nitric oxide plays a role in neural dysregulation.
  • Emerging therapies show promise in targeting central sympathetic pathways.

Conclusions:

  • Central sympathetic overactivity is a critical factor in various disease states.
  • Understanding the role of nitric oxide is crucial for developing new treatments.
  • Targeting central sympathetic pathways offers a promising therapeutic avenue.