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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
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Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

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Published on: August 1, 2013

Circulating dendritic cells following burn.

N D'Arpa1, A Accardo-Palumbo, G Amato

  • 1Plastic Surgery and Burns Therapy Operating Unit, ARNAS, Civic Hospital, Piazza Leotta 4, 90127 Palermo, Italy. lab.biotecno@ospedalecivicopa.org

Burns : Journal of the International Society for Burn Injuries
|March 10, 2009
PubMed
Summary
This summary is machine-generated.

Severe burns can lead to sepsis and immune suppression. This study found reduced dendritic cells (DCs), crucial for immune response, in burn patients with sepsis, suggesting a link to immunosuppression.

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Area of Science:

  • Immunology
  • Burn Injury Research
  • Sepsis Pathogenesis

Background:

  • Severe burns trigger immune suppression, increasing sepsis risk.
  • Dendritic cells (DCs) are vital for coordinating immune responses to pathogens.
  • Understanding DC subset dynamics in burn sepsis is crucial for host defense.

Purpose of the Study:

  • To investigate the levels of myeloid (mDC) and plasmacytoid (pDC) dendritic cell subsets in burn patients with sepsis.
  • To determine if DC deficiencies correlate with sepsis development and outcomes in burn victims.

Main Methods:

  • Utilized multicolour flow cytometry to analyze peripheral blood samples.
  • Quantified percentages of mDCs (LIN(-) DR(+) CD11c(+)) and pDCs (LIN(-) DR(+) CD123(+)).
  • Compared DC subsets in septic burn survivors and non-survivors, non-septic burn victims, and healthy controls.

Main Results:

  • Significant reductions in circulating mDCs and pDCs were observed in septic burn patients (survivors and non-survivors) compared to controls.
  • These reductions were statistically significant (p<0.001).
  • DC subset deficiencies were evident up to 20 days post-injury.

Conclusions:

  • Deficiencies in myeloid and plasmacytoid dendritic cell subsets are associated with sepsis following severe burns.
  • Reduced DC levels may contribute to the immunosuppression observed in burn victims.
  • Further research into DC function post-burn is warranted to improve patient outcomes.