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Related Experiment Video

Updated: Jun 25, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

Quetiapine-induced peripheral edema.

Kausik Roy¹, Vera Astreika, Jonathan E Dunn

¹Department of Internal Medicine, Case Western Reserve University at MetroHealth Campus, Cleveland, OH, USA.

General Hospital Psychiatry

|March 10, 2009

Summary

This study details a rare side effect of quetiapine fumarate, an atypical antipsychotic. Peripheral edema was observed, highlighting a less common adverse reaction to this medication.

Related Experiment Videos

Last Updated: Jun 25, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

Area of Science:

Pharmacology
Clinical Medicine
Adverse Drug Reactions

Background:

Quetiapine fumarate is an atypical antipsychotic medication.
It is generally recognized for a favorable side-effect profile.
Understanding all potential adverse effects is crucial for patient safety.

Observation:

This report documents a rare instance of peripheral edema associated with quetiapine use.
This represents the second reported case of this specific side effect.
The patient experienced this adverse reaction without prior awareness.

Findings:

Peripheral edema is an identified, albeit rare, side effect of quetiapine fumarate.
The occurrence of this side effect necessitates increased clinical awareness.
Misdiagnosis due to unawareness can lead to unnecessary patient investigations.

Implications:

Clinicians should be aware of peripheral edema as a potential side effect of quetiapine.
Early recognition can prevent extensive and unnecessary diagnostic workups.
This case contributes to the literature on rare adverse drug reactions of atypical antipsychotics.