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Related Experiment Video

Updated: Jun 25, 2026

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting
08:28

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting

Published on: June 30, 2017

New developments in adipogenesis.

Martina I Lefterova1, Mitchell A Lazar

  • 1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Trends in Endocrinology and Metabolism: TEM
|March 10, 2009
PubMed
Summary
This summary is machine-generated.

This review explores adipogenesis, the process of fat cell development. Understanding regulators of brown and white adipocytes may offer new obesity and metabolic disease treatments.

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Area of Science:

  • Cell Biology
  • Metabolic Science

Background:

  • The global obesity epidemic highlights the importance of adipose tissue and adipogenesis (fat cell development).
  • Key regulators like peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins have been identified.
  • Genome-wide studies reveal significant overlap in the transcriptional targets of these regulators.

Purpose of the Study:

  • To review recent advancements in adipogenesis research.
  • To highlight newly identified determinants of brown adipocytes, which dissipate energy.
  • To discuss the potential for improved obesity and metabolic disease treatments through a better understanding of adipocyte biology.

Main Methods:

  • Literature review of recent studies on adipogenesis.
  • Analysis of genome-wide studies identifying transcriptional targets.
  • Synthesis of information on positive and negative regulators of adipocyte development.

Main Results:

  • Identification of novel factors regulating adipocyte development.
  • Characterization of specific determinants for brown adipocytes.
  • Evidence for widespread overlap in transcriptional targets of key adipogenesis regulators.

Conclusions:

  • Advances in understanding adipogenesis, particularly brown adipocyte function, are crucial.
  • Integrating knowledge of white and brown adipocyte origins and biology can inform obesity and metabolic disease therapies.