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Updated: Jun 25, 2026

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation
Published on: January 24, 2025
UV light inactivation of bacterial biothreat agents
1Centers for Disease Control and Prevention, NCID/DHQP/ILB, 1600 Clifton Rd. NE, MS C-16, Atlanta, GA 30329, USA. lrose@cdc.gov
Abstract:
Seven species of bacterial biothreat agents were tested for susceptibility to UV light (254 nm). All gram-negative organisms tested required <12 mJ/cm(2) for a 4-log(10) reduction in viability (inactivation). Tailing off of the B. anthracis spore inactivation curves began close to the 2-log(10) inactivation point, with a fluence of approximately 40 mJ/cm(2), and 3-log(10) inactivation still was not achieved with a fluence of 120 mJ/cm(2).
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