Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ILC2s regulate a fibroblast progenitor niche in the pancreas.

Science (New York, N.Y.)·2026

Same author

Correction: Shyamsunder et al. THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors. <i>Int. J. Mol. Sci.</i> 2022, <i>23</i>, 1207.

International journal of molecular sciences·2026

Same author

In Silico-Enabled Discovery and Development of Potent and Selective CDK11 Inhibitors.

ChemMedChem·2026

Same author

Mesenchymal stromal cells modulate survival and regeneration of human hematopoietic stem cells via PGE2/cAMP signaling.

Cell death & disease·2026

Same author

Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells.

Cell reports·2025

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Hematopoietic stem cell transplantation without irradiation.

Claudia Waskow¹, Vikas Madan, Susanne Bartels

¹Center for Regenerative Therapies Dresden, Dresden University of Technology, Germany. claudia.waskow@crt-dresden.de

|March 10, 2009

Summary

Researchers developed a universal mouse model for hematopoietic stem cell (HSC) transplantation. This model overcomes histocompatibility barriers and niche competition, enabling HSC studies without prior irradiation.

More Related Videos

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

Related Experiment Videos

Last Updated: Jun 25, 2026

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

Area of Science:

Immunology
Hematology
Stem Cell Biology

Background:

Hematopoietic stem cell (HSC) transplantation faces limitations due to histocompatibility issues and bone marrow niche availability.
These challenges hinder in vivo research on histoincompatible stem cells and HSC function in non-irradiated settings.

Purpose of the Study:

To create a universal recipient model for efficient HSC transplantation.
To overcome histocompatibility barriers and bone marrow niche limitations for HSC research.

Main Methods:

Genetically engineered mice by combining immunodeficiency with impaired Kit growth factor receptor function.
Utilized this model to assess long-term acceptance of both histocompatible and histoincompatible HSCs.

Main Results:

The developed mouse model functions as a 'universal' recipient for HSC transplantation.
Achieved efficient, long-term acceptance of both histocompatible and histoincompatible HSCs.
Transplantation was successful without the need for prior irradiation of the recipient mice.

Conclusions:

The novel universal HSC recipient model significantly advances the study of stem cell transplantation.
This model facilitates in vivo analysis of HSCs, including histoincompatible and mutant stem cells, under non-irradiated conditions.