Related Experiment Video
Updated: Jun 25, 2026

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
Published on: December 19, 2025
[Thrombolysis of the middle cerebral artery]
C Brekenfeld1, J Gralla, H-P Mattle
1Institut für Diagnostische und Interventionelle Neuroradiologie, Inselspital Bern, Freiburgstr. 4, CH-3010, Bern, Schweiz. caspar.brekenfeld@insel.ch
Abstract:
Intravenous thrombolysis (IVT) is the evidence-based treatment of acute ischemic stroke in the first 3 h after symptom onset (IVT 3-4.5 h: off-label use with informed consent of the patient). However, intra-arterial thrombolysis (IAT) results in higher recanalization rates of the middle cerebral artery compared to IVT. Therefore it seems reasonable to apply IAT in addition or instead of IVT up to 6 h after symptom onset.
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