Related Experiment Video
Updated: Jun 25, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
Published on: October 14, 2025
[Main therapeutic advances in IBD in 2008]
Adding azathioprine or methotrexate to infliximab for Crohn's disease does not enhance treatment effectiveness. This combination therapy increases risks for infections and new cancers.
Area of Science:
- Gastroenterology and Immunology
- Pharmacology and Therapeutics
Context:
- Crohn's disease management
- Infliximab therapy
- Combination immunosuppression
Purpose:
- Evaluate the efficacy and safety of combination immunosuppression (azathioprine or methotrexate with infliximab) in Crohn's disease.
- Assess the impact on therapeutic outcomes and adverse events.
Summary:
- Coimmunosuppression with azathioprine or methotrexate alongside infliximab did not improve therapeutic efficacy in Crohn's disease.
- This combination therapy was associated with increased risks of infectious complications and neoplasia.
Impact:
- Findings suggest infliximab monotherapy may be preferred in Crohn's disease to minimize adverse events.
- Highlights the importance of risk-benefit assessment in immunosuppressive therapy for inflammatory bowel disease.
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Published on: December 15, 2017
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