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Liver Physiology

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...

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Related Experiment Video

Updated: Jun 25, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

[Highlights in hepatology].

I Pache¹, E-L Leung Ki, A Antonino

¹Service de gastroentérologie et d'hépatologie, CHUV, 1011 Lausanne. Isabelle.Pache@chuv.ch

Revue Medicale Suisse

|March 11, 2009

Summary

This summary is machine-generated.

This review covers recent hepatology advances, including hereditary hemochromatosis, new hepatitis C treatments, and therapies for liver disease complications like ascites and thrombocytopenia. It also discusses chronic hepatitis E and sorafenib for advanced hepatocellular carcinoma.

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Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

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Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Published on: August 14, 2017

Area of Science:

Hepatology and gastroenterology.
Internal medicine and clinical practice.

Context:

Recent breakthroughs in liver disease management.
Focus on hereditary hemochromatosis, viral hepatitis, and hepatocellular carcinoma.

Purpose:

To critically review and summarize recent advances in hepatology.
To discuss the clinical implications of these developments.

Summary:

Highlights include clinical penetrance of hereditary hemochromatosis.
New treatments for chronic hepatitis C, thrombocytopenia in cirrhosis, and portal hypertension complications (ascites, hyponatremia).
Discusses chronic hepatitis E in immunosuppressed patients and sorafenib for advanced hepatocellular carcinoma.

Impact:

Provides insights into current and future clinical practice in hepatology.
Emphasizes the potential impact of novel therapies on patient outcomes.
Facilitates informed decision-making for healthcare professionals managing liver diseases.