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Related Experiment Video

Updated: Jun 25, 2026

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Chronic fatigue: is it endocrinology?

Kate M Evans¹, Daniel E Flanagan, Terence J Wilkin

¹Department of Endocrinology and Metabolism, Peninsula Medical School, Plymouth and Derriford Hospital, Plymouth. kme@doctors.org.uk

Clinical Medicine (London, England)

|March 11, 2009

Summary

Patients referred for fatigue without clear endocrine issues do not develop significant future health problems. This suggests fatigue diagnoses are reliable and not early signs of hidden endocrine disease.

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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Area of Science:

Endocrinology
Internal Medicine
Clinical Diagnostics

Background:

Fatigue and stress-related conditions are often diagnoses of exclusion.
Patients frequently seek endocrine evaluation for persistent tiredness.
The long-term outcomes for such patients are not well-established.

Purpose of the Study:

To investigate the long-term outcomes of patients referred for fatigue.
To determine if initial assessments for subtle endocrine pathology are reliable.
To ascertain if fatigue symptoms predict future endocrine disease.

Main Methods:

A five-year prospective study of 101 patients.
Patients were referred for unexplained fatigue with no initial signs of treatable endocrine pathology.
Outcomes assessed included morbidity, mortality, and development of endocrine disorders.

Main Results:

The clinical diagnosis of fatigue was deemed secure.
Patients did not exhibit excess morbidity or mortality over five years.
Presenting fatigue symptoms were not indicative of significant future endocrine pathology.

Conclusions:

Initial clinical assessment for fatigue, excluding common endocrine disorders, is reliable.
Patients with unexplained fatigue do not typically develop serious endocrine conditions later.
The diagnosis of fatigue as a standalone issue is often accurate.