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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Urinary Bladder01:23

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Updated: Jun 25, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

Bladder dysfunction in multiple sclerosis.

Pamela A McCombe1, Thomas P Gordon, Michael W Jackson

  • 1Center for Clinical Research, The University of Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, Australia. pamela.mccombe@uq.edu.au

Expert Review of Neurotherapeutics
|March 11, 2009
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) causes bladder dysfunction, often linked to neural pathway damage. Researchers are exploring other causes and receptor targets for potential treatments.

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Real-Time Void Spot Assay
06:39

Real-Time Void Spot Assay

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Last Updated: Jun 25, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

Real-Time Void Spot Assay
06:39

Real-Time Void Spot Assay

Published on: February 10, 2023

Area of Science:

  • Neurology
  • Immunology
  • Urology

Background:

  • Multiple sclerosis (MS) is a common neurological disease affecting young adults, characterized by demyelination, inflammation, and neurodegeneration.
  • Bladder dysfunction is a frequent symptom in MS patients, impacting quality of life and potentially leading to disability.
  • Current understanding attributes bladder issues primarily to neural pathway damage, but correlations with MRI lesions are inconsistent.

Purpose of the Study:

  • To investigate the underlying causes of bladder dysfunction in multiple sclerosis.
  • To explore potential alternative mechanisms beyond demyelination and axonal loss.
  • To identify therapeutic targets for managing bladder symptoms in MS.

Main Methods:

  • Review of existing literature on MS pathology and neurogenic bladder.
  • Analysis of the neural control of micturition and sensory pathways.
  • Exploration of potential roles for circulating factors and specific receptors.

Main Results:

  • Bladder dysfunction in MS is multifactorial, with neural pathway damage being a primary but not sole contributor.
  • The lack of strong correlation between MRI lesions and bladder symptoms suggests other pathogenic mechanisms.
  • Urgency of micturition is a prominent symptom, indicating the involvement of specific sensory receptors.

Conclusions:

  • While demyelination and neurodegeneration contribute to MS-related bladder issues, circulating toxic factors may also play a role.
  • Understanding bladder sensory receptors offers promising avenues for developing targeted treatments.
  • Further research into non-lesional causes of bladder dysfunction is warranted for comprehensive MS management.