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Fine needle aspiration diagnosis of Penicillium marneffei infection
Abstract:
A disseminated infection with Penicillium marneffei, a rare human pathogen that may infect both healthy and immunocompromised patients, was diagnosed by fine needle aspiration cytology in a patient infected with the human immunodeficiency virus. The presence of yeast-form organisms with an eccentric or central dot and occasional septate and elongated forms highly suggested the diagnosis, which was confirmed on culture. Establishment of the diagnosis is important because this infection is potentially curable.
Insights
A disseminated Penicillium marneffei infection was diagnosed in an HIV-positive patient using fine needle aspiration cytology. Early diagnosis is crucial as this rare fungal infection is treatable.
Area of Science:
- Mycology
- Infectious Diseases
- Medical Diagnostics
Background:
- Penicillium marneffei is a dimorphic fungus causing a rare systemic infection.
- Infection can occur in both immunocompetent and immunocompromised individuals.
- Human immunodeficiency virus (HIV) infection is a risk factor for disseminated disease.
Observation:
- Fine needle aspiration cytology (FNAC) was used for diagnosis.
- Microscopic examination revealed yeast-form organisms with characteristic features.
- Morphological findings included organisms with an eccentric or central dot, and occasional septate and elongated forms.
Findings:
- FNAC findings strongly suggested disseminated Penicillium marneffei infection.
- Diagnosis was confirmed by fungal culture.
- The patient was diagnosed with HIV.
Implications:
- Early and accurate diagnosis of Penicillium marneffei is critical.
- This disseminated fungal infection is potentially curable with appropriate treatment.
- FNAC is a valuable tool for rapid diagnosis in resource-limited settings.