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MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans
Xin-Chun Yang1, Qi Zhang, Mu-Lei Chen
1Heart Center, Beijing Chaoyang Hospital, Institute of Cardiovascular Disease, Capital University of Medical Sciences, Beijing 100020, China.
Insights
Genetic variations in the cyclin-dependent kinase inhibitor 2B (CDKN2B) and methylthioadenosine phosphorylase (MTAP) genes are linked to myocardial infarction (MI) risk in Chinese males. This research highlights potential genetic factors influencing heart attack susceptibility.
Area of Science:
- Genetics
- Cardiovascular Disease
- Molecular Biology
Background:
- Myocardial infarction (MI) is a leading cause of mortality globally.
- Genetic predisposition plays a significant role in the development of MI.
- The role of specific gene polymorphisms in MI risk among Chinese Han populations requires further investigation.
Purpose of the Study:
- To examine the association between polymorphisms in the cyclin-dependent kinase inhibitor 2A (CDKN2A), cyclin-dependent kinase inhibitor 2B (CDKN2B), and methylthioadenosine phosphorylase (MTAP) genes and the risk of MI.
- To identify specific genetic variants that may influence MI susceptibility in Chinese Han individuals.
Main Methods:
- A case-control study involving 432 MI patients and 430 healthy controls from the Chinese Han population.
- Tagging single nucleotide polymorphism (tSNP) strategy was employed to select nine polymorphisms in the MTAP gene, two in CDKN2A, and two in CDKN2B.
- Genotyping was performed to analyze the selected polymorphisms.
Main Results:
- Significant associations were found between specific polymorphisms (rs7027989 in MTAP; rs3217992 and rs1063192 in CDKN2B) and MI risk in male subjects.
- Male subjects with AA or AG genotypes for rs7027989 and rs3217992 showed an increased risk of MI (ORs 1.26 and 1.24, respectively).
- The G allele of rs1063192 was associated with a reduced MI risk in males (per-allele OR 0.71).
Conclusions:
- Polymorphisms in the CDKN2B and MTAP genes are associated with an altered risk of myocardial infarction in the Chinese Han population.
- These findings suggest that genetic variations in CDKN2B and MTAP may contribute to MI susceptibility.
- This study provides novel insights into the genetic underpinnings of MI in this demographic group.
Objectives:
To investigate the association between cyclin-dependent kinase inhibitor 2A (CDKN2A) gene, cyclin-dependent kinase inhibitor 2B (CDKN2B) gene, and methylthioadenosine phosphorylase (MTAP) gene and myocardial infarction (MI) in Chinese Hans.
Design And Methods:
A total of 432 patients with MI and 430 controls were included in the study. Nine polymorphisms in the MTAP gene, two polymorphisms in the CDKN2A gene, and two polymorphisms in the CDKN2B gene were selected using a tagging single nucleotide polymorphism (tSNP) strategy.
Results:
We observed that rs7027989 in the MTAP gene, and rs3217992 and rs1063192 in the CDKN2B gene were significantly associated with MI in male subjects. For rs7027989 and rs3217992, male subjects with the AA or AG genotypes had 1.26-fold and 1.24-fold increased risk of MI, respectively, compared with those with the GG genotype. For rs1063192, the G allele was associated with a reduced risk of MI with a per-allele OR of 0.71 in male subjects. The risk of rs7027989 and rs1063192 remained significant after adjusting for covariates.
Conclusions:
This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of MI in Chinese.
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