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Related Experiment Videos

Dexamethasone suppression test in depressive stroke patients.

H Dam1, H E Pedersen, M Damkjaer

  • 1Neurology Department, Glostrup Hospital, Denmark.

Acta Neurologica Scandinavica
|July 1, 1991
PubMed
Summary

Depression in stroke patients was assessed using the dexamethasone suppression test (DST). No difference in DST non-suppression was found between depressive and non-depressive stroke patients, but right-hemisphere lesions correlated with higher cortisol levels.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Endocrinology

Background:

  • Depression is common in stroke patients.
  • Depressive psychiatric patients often exhibit non-suppression on the dexamethasone suppression test (DST).
  • The relationship between stroke, depression, and DST response requires further investigation.

Purpose of the Study:

  • To investigate the utility of the DST in identifying depression in stroke patients.
  • To examine the correlation between hemispheric lesion location and DST response in stroke patients.

Main Methods:

  • The DST was administered to 76 stroke patients and 26 controls.
  • Postdexamethasone plasma cortisol levels were measured at 8 a.m.
  • Patients were categorized based on the presence or absence of depression and the location of the brain lesion (right vs. left hemisphere).

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Main Results:

  • No significant difference in DST non-suppression frequency was observed between depressive and non-depressive stroke patients.
  • Stroke patients with lesions in the right hemisphere showed significantly higher postdexamethasone plasma cortisol levels compared to those with left hemisphere lesions.

Conclusions:

  • The DST may not be a reliable indicator for depression in stroke patients.
  • Hemispheric lateralization of brain lesions influences the neuroendocrine response to DST in stroke survivors.
  • Right-hemisphere lesions in stroke patients are associated with altered cortisol regulation.