FactorY, a bioinformatic resource for genome-wide promoter analysis

Elizabeth Guruceaga1, Victor Segura, Fernando J Corrales

  • 1Unit of Proteomics, Genomics and Bioinformatics, CIMA, Pamplona 31008, Spain. eguruce@unav.es

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The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
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Transcription of prokaryotic...
Prokaryotic Transcriptional Activators and Repressors01:58

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Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
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