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Weight changes associated with unilateral STN DBS and advanced PD.

Harrison C Walker1, Michael Lyerly, Gary Cutter

  • 1Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. hcwalker@uab.edu

Parkinsonism & Related Disorders
|March 11, 2009
PubMed
Summary

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Unilateral subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson disease (PD) patients leads to significant weight gain within one year. This weight increase helps counteract the weight loss often seen in advanced PD.

Area of Science:

  • Neurology
  • Neurosurgery
  • Metabolic Research

Background:

  • Parkinson disease (PD) is often associated with weight loss.
  • Bilateral subthalamic nucleus deep brain stimulation (STN DBS) in PD patients has been linked to weight gain.
  • Limited data exists on weight changes after unilateral STN DBS.

Purpose of the Study:

  • To evaluate weight changes in Parkinson disease patients following unilateral STN DBS.
  • To compare weight changes in unilateral STN DBS patients with their preoperative weight and with matched PD controls.

Main Methods:

  • A case-control study involving 39 PD patients undergoing unilateral STN DBS.
  • Weight changes were measured over 1 year post-surgery.
  • Comparison with preoperative weight changes and 40 age- and disease severity-matched PD controls without DBS.

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  • Regression analyses were used to assess weight changes.

    • Main Results:

    • Patients gained an average of 4.3 kg at 12 months post-unilateral STN DBS (p<0.001).
    • This weight gain was significantly greater by 4.8 kg compared to controls (p=0.015).
    • Weight gain occurred in 85% of unilateral STN DBS patients at 12 months (p<0.0001).

    Conclusions:

    • Unilateral STN DBS in PD patients is associated with significant weight gain.
    • This weight gain may offset the weight loss typically observed in advanced PD.
    • Unilateral STN DBS is a potential intervention for managing weight loss in PD.