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Updated: Jun 25, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
Published on: September 20, 2019
Chemokines and chemokine receptors: an overview
Raffaella Bonecchi1, Emanuela Galliera, Elena Monica Borroni
1Department of Translational Medicine, University of Milan, IRCCS Istituto Clinico Humanitas, I-20089 Rozzano, Italy.
Abstract:
Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value.
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