Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted cleavage site mutations in the Gn precursor enable efficient generation of replication-competent rVSV-based surrogates for emerging nairoviruses.

Emerging microbes & infections·2026
Same author

ISG15-USP18 signaling restrains viperin-dependent metabolic antiviral restriction.

bioRxiv : the preprint server for biology·2026
Same author

Nucleoprotein and glycoprotein based serological assays for detection of Marburg virus infections.

EBioMedicine·2026
Same author

Human antibody targeting Crimean-Congo hemorrhagic fever virus glycoprotein 38 protects mice against heterologous virus challenge.

The Journal of clinical investigation·2026
Same author

Strength vs. endurance in myotome assessment-a case for (further studies on) repeated measurements.

Frontiers in rehabilitation sciences·2026
Same author

Confirming ERVEBO Vaccination to Support Ebola Virus Surveillance.

Emerging infectious diseases·2026
Same journal

AKT-mTOR/P53 PathwayDriven RapamycinAlpelisib Efficacy in Animal Models of TIE2Mutant Venous Malformations.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Dual Role of Nitric Oxide in Tumor Immunity and Its Therapeutic Application.

Frontiers in bioscience (Landmark edition)·2026
Same journal

The Metabolic States of Cancer-Associated Fibroblasts: Targeting Stromal Reprogramming to Impede Tumor Progression and Immune Evasion.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Functional Changes in Mitochondrial Subpopulations of Left Ventricular Cardiomyocytes in Post-Infarction Rats During the Subacute Stage of Remodeling.

Frontiers in bioscience (Landmark edition)·2026
Same journal

TRPM7 Channel-Mediated Mitochondrial Oxidative Stress Induces Dysfunction of Müller Cells Under High Glucose and Low Mg<sup>2+</sup> Stress.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Navigating the Redox Precipice: Metabolic Gatekeeping as a Therapeutic Window in Pancreatic Precancer.

Frontiers in bioscience (Landmark edition)·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Bone cells-biomaterials interactions.

Marie-Eve Marquis1, Etienne Lord, Eric Bergeron

  • 1Laboratory of Cells-Biomaterials Biohybrid Systems, Universite de Sherbrooke, Department of Chemical Engineering and Biotechnological Engineering, 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1.

Frontiers in Bioscience (Landmark Edition)
|March 11, 2009
PubMed
Summary
This summary is machine-generated.

Bone defects are increasing, driving demand for bone replacement alternatives. This review examines cell-biomaterial interactions, crucial for developing effective bone tissue engineering strategies.

More Related Videos

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
04:32

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

Related Experiment Videos

Last Updated: Jun 25, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions
04:32

Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Aging population increases bone defects, straining healthcare resources.
  • Autografts are standard for bone replacement but have limitations like donor site morbidity and limited quantity.
  • Biomaterials are being explored as alternatives to autografts for bone repair.

Purpose of the Study:

  • To review the interactions between bone cells and biomaterials.
  • To highlight the importance of controlling cell-biomaterial interactions for successful bone regeneration.
  • To focus on studies examining these interactions in two-dimensional systems.

Main Methods:

  • Literature review focusing on cell-biomaterial interactions.
  • Analysis of studies investigating cell adhesion, proliferation, and differentiation on biomaterials.
  • Emphasis on two-dimensional experimental systems.

Main Results:

  • Cell-biomaterial interactions are critical for implant integration and scaffold colonization.
  • Controlling these interactions influences key cellular processes like proliferation and differentiation.
  • Two-dimensional systems have been extensively used to study these fundamental interactions.

Conclusions:

  • Understanding cell-biomaterial interactions is essential for designing effective bone regenerative therapies.
  • Biomaterial development must consider cell adhesion and subsequent biological responses.
  • Further research into cell-biomaterial interactions will advance bone tissue engineering.