Jove
Visualize
Contact Us

Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune hyperactivity in hemodialysis patients is associated with interferon gamma-induced trained immunity.

iScience·2026
Same author

HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance.

Circulation·2026
Same author

Advancing Hope Through Science: The Inaugural Richard Slayman International Workshop on Xenotransplantation.

Transplantation·2026
Same author

Dominant intragraft plasma cells targeting bilirubin implicate local heme catabolism in human cardiac allograft vasculopathy.

The Journal of clinical investigation·2025
Same author

In vitro protocol demonstrating five functional steps of trained immunity in mice: Implications on biomarker discovery and translational research.

Cell reports·2025
Same author

Cryopreservation Strategies to Improve Access to Organ Transplantation.

Transplantation·2025
Same journal

AKT-mTOR/P53 PathwayDriven RapamycinAlpelisib Efficacy in Animal Models of TIE2Mutant Venous Malformations.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Dual Role of Nitric Oxide in Tumor Immunity and Its Therapeutic Application.

Frontiers in bioscience (Landmark edition)·2026
Same journal

The Metabolic States of Cancer-Associated Fibroblasts: Targeting Stromal Reprogramming to Impede Tumor Progression and Immune Evasion.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Functional Changes in Mitochondrial Subpopulations of Left Ventricular Cardiomyocytes in Post-Infarction Rats During the Subacute Stage of Remodeling.

Frontiers in bioscience (Landmark edition)·2026
Same journal

TRPM7 Channel-Mediated Mitochondrial Oxidative Stress Induces Dysfunction of Müller Cells Under High Glucose and Low Mg<sup>2+</sup> Stress.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Navigating the Redox Precipice: Metabolic Gatekeeping as a Therapeutic Window in Pancreatic Precancer.

Frontiers in bioscience (Landmark edition)·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 25, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Immunosuppression for lung transplantation.

Choo Y Ng1, Joren C Madsen, Bruce R Rosengard

  • 1Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Frontiers in Bioscience (Landmark Edition)
|March 11, 2009
PubMed
Summary
This summary is machine-generated.

Lung transplantation survival is limited by allograft rejection and infection. Current immunosuppression strategies face a paradox, balancing rejection prevention with infection risk.

More Related Videos

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Related Experiment Videos

Last Updated: Jun 25, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Area of Science:

  • Medical research
  • Surgical innovation
  • Immunology

Background:

  • Lung transplantation is a viable treatment for end-stage lung disease, with 1-year survival near 80%.
  • Five-year survival has stagnated around 50% due to acute and chronic lung allograft rejection.
  • Current immunosuppressive therapy presents a therapeutic paradox: insufficient suppression leads to rejection, while excess leads to infection and malignancy.

Purpose of the Study:

  • To review the current state of immunosuppressive therapy in lung transplantation.
  • To explore alternative management strategies for lung transplant recipients.

Main Methods:

  • Literature review of current immunosuppressive therapies.
  • Analysis of survival rates and causes of mortality in lung transplant recipients.
  • Discussion of therapeutic challenges and future directions.

Main Results:

  • Graft rejection, opportunistic infections, and malignancies are the primary causes of mortality.
  • Lung allograft loss is often fatal due to limited support options and donor graft scarcity.
  • Existing immunosuppression protocols struggle to balance efficacy and toxicity.

Conclusions:

  • Novel immunosuppressive paradigms are needed to improve long-term lung transplant outcomes.
  • Addressing the rejection-infection-malignancy triad is crucial for recipient survival.
  • Future strategies should aim to optimize immunosuppression, reducing both rejection and treatment-related complications.