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Updated: Jun 25, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Apoptotic signaling cascades operating in poliovirus-infected cells

Bruno Blondel1, Arnaud Autret, Cynthia Brisac

  • 1Biologie des Virus Enteriques, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris cedex 15, France. bblondel@pasteur.fr

Frontiers in Bioscience (Landmark Edition)
|March 11, 2009
PubMed

Insights

Poliovirus (PV) causes motor neuron apoptosis, leading to paralysis. Mitochondrial dysfunction, driven by imbalanced apoptotic pathways, is key to this cell death, advancing our understanding of poliomyelitis.

Area of Science:

  • Neuroscience
  • Virology
  • Cell Biology

Background:

  • Poliomyelitis, characterized by flaccid paralysis, results from poliovirus (PV) infection of motor neurons.
  • PV infection triggers apoptosis, or programmed cell death, in motor neurons.
  • The precise mechanisms of PV-induced neuronal cell death are not fully understood.

Purpose of the Study:

  • To review recent studies on poliovirus-induced apoptosis.
  • To elucidate the role of mitochondria in PV-induced neuronal cell death.
  • To enhance the understanding of poliomyelitis pathogenesis.

Main Methods:

  • Analysis of apoptotic pathways in PV-infected cell lines.
  • Investigation of mitochondrial involvement in PV-induced apoptosis.
  • Review of existing research on PV and neuronal cell death.

Main Results:

  • Mitochondria play a crucial role in PV-induced apoptosis.
  • PV infection leads to mitochondrial dysfunction.
  • This dysfunction arises from an imbalance between pro-apoptotic and anti-apoptotic pathways.

Conclusions:

  • Mitochondrial dysfunction is a central mechanism in poliovirus-induced motor neuron apoptosis.
  • Understanding these apoptotic pathways is critical for comprehending poliomyelitis.
  • Further research into these pathways may reveal therapeutic targets.

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