Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatic Spinal Reflexes01:22

Somatic Spinal Reflexes

Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Youth Soccer Participation and Brain Health Outcomes in Adolescent Athletes.

JAMA network open·2026
Same author

Research priorities for advancing mental health in elite sport: a companion to the IOC consensus statement on mental health in elite athletes.

British journal of sports medicine·2026
Same author

From plan to practice: Development, awareness, and implementation of sports injury and illness risk management plans in a professional male football setting.

Journal of science and medicine in sport·2026
Same author

Response to: Comment on "The Practical Value of Bayesian Inference in Describing the Epidemiology of Sports Injuries".

Sports medicine (Auckland, N.Z.)·2026
Same author

A holistic approach for consistent image quality and dose in digital radiography in a large imaging enterprise.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

Global survey of microscopy core facilities.

Journal of microscopy·2026

Related Experiment Video

Updated: Jun 25, 2026

A Protocol to Acquire the Degenerative Tenocyte from Humans
09:25

A Protocol to Acquire the Degenerative Tenocyte from Humans

Published on: June 9, 2018

Neuropeptides in tendinopathy.

Alexander Scott1, Roald Bahr

  • 1Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada. ascott@interchange.ubc.ca

Frontiers in Bioscience (Landmark Edition)
|March 11, 2009
PubMed
Summary

Overuse tendinopathy involves nerves and neuropeptides. Tenocytes may intrinsically produce these substances, impacting treatment strategies for conditions like tendinopathy.

Area of Science:

  • Sports Medicine
  • Neuroscience
  • Cell Biology

Background:

  • Overuse tendinopathy presents a significant clinical challenge.
  • Emerging research implicates sensory and autonomic nerves in tendinopathy pathology.
  • Neuropeptides and their role in tendinopathy symptoms and tissue changes are increasingly recognized.

Purpose of the Study:

  • To review the neuroanatomy and neuropeptide involvement in tendinopathy.
  • To explore the potential intrinsic source of neuropeptides within tendon cells (tenocytes).
  • To discuss the implications for conservative tendinopathy management.

Main Methods:

  • Literature review focusing on neuroanatomy and neuropeptide function in tendinopathy.
  • Analysis of recent studies on intrinsic neuropeptide production by tenocytes.

More Related Videos

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair
08:32

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement
08:19

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

Published on: December 8, 2023

Related Experiment Videos

Last Updated: Jun 25, 2026

A Protocol to Acquire the Degenerative Tenocyte from Humans
09:25

A Protocol to Acquire the Degenerative Tenocyte from Humans

Published on: June 9, 2018

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair
08:32

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement
08:19

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

Published on: December 8, 2023

  • Discussion of clinical implications for therapeutic interventions.

    • Main Results:

    • Nerves and associated neuropeptides play a role in tendinopathy.
    • Tenocytes represent a potential intrinsic source of neuropeptides within tendons.
    • Substance P and mast cells are highlighted for their potential roles.

    Conclusions:

    • Understanding the neurobiology of tendinopathy, including intrinsic neuropeptide sources, is crucial.
    • Conservative management strategies like sclerosing injections and exercise training may be informed by these findings.