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Updated: Jun 25, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
The enterohepatic circulation of bile acids in mammals: form and functions
1Division of Gastroenterology. Department of Medicine, University of California, San Diego. La Jolla, California 92093-0063, USA. ahofmann@ucsd.edu
Abstract:
The features of the enterohepatic circulation of bile acids in mammals are reviewed. Inputs into the circulating bile acids are primary bile acids synthesized from cholesterol in the hepatocyte and secondary bile acids formed by bacterial modification of primary bile acids in the distal intestine. Intestinal conservation of bile acids generates pools of individual bile acids whose relative sizes determine biliary bile acid composition. Efficient hepatic clearance results in low plasma bile acid levels, and virtually no renal excretion. Methods for characterizing the enterohepatic circulation are summarized. Bile acids have numerous physiological functions in the liver, biliary tract, and intestine resulting from their signaling and physicochemical properties.
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