Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 25, 2026

Using Looming Visual Stimuli to Evaluate Mouse Vision
05:07

Using Looming Visual Stimuli to Evaluate Mouse Vision

Published on: June 13, 2019

Vision tests in the mouse: Functional phenotyping with electroretinography.

Naoyuki Tanimoto1, Regine L Muehlfriedel, M Dominik Fischer

  • 1Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Schleichstrasse 4/3, D-72076 Tuebingen, Germany. naoyuki.tanimoto@med.unituebingen.de

Frontiers in Bioscience (Landmark Edition)
|March 11, 2009
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pre-existing retinal inflammation exacerbates gene therapy-associated uveitis in more rapidly progressive retinal degeneration.

Molecular therapy. Advances·2026
Same author

Subretinal injection in the USH1CR31∗ pig model leads to chorioretinal atrophy that limits evaluation of efficacy of an AAV-mediated gene therapy.

Experimental eye research·2026
Same author

HCN4 gain-of-function mutation increases intrinsic heart rate and limits maladaptive remodeling under pressure overload.

Frontiers in pharmacology·2026
Same author

Gene therapy development for retinal diseases.

Handbook of clinical neurology·2026
Same author

Expert Consensus on Characteristics, Etiology, and Management of Chorioretinal Atrophy in Patients Treated with Voretigene Neparvovec.

Ophthalmology science·2026
Same author

[On the urgency of treating ophthalmic emergencies].

Die Ophthalmologie·2026

Electroretinography (ERG) provides objective retinal function data. This study details ERG methods using mouse models to understand retinal disease and rod/cone contributions.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Genetics

Background:

  • Electroretinography (ERG) is a key diagnostic tool in ophthalmology.
  • Animal models, particularly transgenic mice, are crucial for studying retinal function and disease.
  • ERG assessment in mice offers advantages over human studies due to fewer examination limitations.

Purpose of the Study:

  • To detail critical aspects for accurate measurement and analysis of retinal responses using ERG.
  • To illustrate the contributions of rod and cone systems to ERG responses.
  • To present exemplary ERG data from normal and genetically modified mice.

Main Methods:

  • Utilized electroretinography (ERG) in wild-type mice.
  • Assessed transgenic mouse models: Rho-/- (cone-only function) and Cnga3-/- (rod-only function).

More Related Videos

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium
09:10

Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium

Published on: July 14, 2020

Related Experiment Videos

Last Updated: Jun 25, 2026

Using Looming Visual Stimuli to Evaluate Mouse Vision
05:07

Using Looming Visual Stimuli to Evaluate Mouse Vision

Published on: June 13, 2019

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium
09:10

Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium

Published on: July 14, 2020

  • Focused on key considerations for proper ERG measurement and data analysis.

    • Main Results:

    • Demonstrated distinct ERG responses in wild-type mice.
    • Showcased altered ERG patterns in Rho-/- and Cnga3-/- mice, highlighting rod and cone system function.
    • Provided exemplary data illustrating the impact of genetic modifications on retinal function.

    Conclusions:

    • ERG is a valuable technique for assessing retinal function in both clinical and research settings.
    • Transgenic mouse models effectively mimic human retinal diseases for electrophysiologic study.
    • ERG analysis in mice provides insights into the specific roles of rod and cone photoreceptors in retinal function and disease.