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Updated: Jun 25, 2026

Production of Modified Autologous Conditioned Serum and Ex Vivo Assessment of Its Healing Potential in Murine Corneal Epithelium

Production of Modified Autologous Conditioned Serum and Ex Vivo Assessment of Its Healing Potential in Murine Corneal Epithelium

Published on: March 24, 2023

Autologous serum for ocular surface diseases.

Guilherme Goulart Quinto¹, Mauro Campos, Ashley Behrens

¹Wilmer Ophthalmological Institute, School of Medicine, The Johns Hopkins University, Baltimore, MD 21287-0005, USA.

Arquivos Brasileiros De Oftalmologia

|March 11, 2009

Summary

Autologous serum eye drops, containing growth factors and other beneficial components, effectively treat various severe dry eye conditions and ocular surface disorders. This review examines recent literature on their therapeutic applications.

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Area of Science:

Ophthalmology
Regenerative Medicine
Biochemistry

Background:

Autologous serum eye drops are utilized for dry eye syndrome, containing growth factors, vitamins, and fibronectin vital for ocular surface health.
Their biochemical composition resembles natural tears, making them well-tolerated and effective for ocular surface repair.
Serum eye drops are prepared as unpreserved blood solutions, leveraging natural healing properties.

Purpose of the Study:

To review recently published literature on ocular surface diseases treated with human autologous serum eye drops.
To consolidate current evidence on the efficacy of autologous serum in managing complex ocular surface conditions.
To highlight the therapeutic potential of autologous serum for a range of eye disorders.

Main Methods:

Systematic literature search of recently published studies.
Review and synthesis of data on autologous serum eye drop applications.
Analysis of treatment outcomes for various ocular surface diseases.

Main Results:

Autologous serum eye drops demonstrate efficacy in treating severe dry eye, Sjögren's syndrome, and other serious ocular surface disorders.
Reported successful treatments include conditions like Stevens-Johnson syndrome, graft-versus-host disease, and persistent corneal erosions.
Effectiveness is noted in managing Mooren's ulcer, neurotrophic keratopathy, and post-surgical complications.

Conclusions:

Autologous serum eye drops are a valuable therapeutic option for numerous ocular surface diseases.
The review supports the continued use and investigation of autologous serum for challenging ophthalmic conditions.
Further research is warranted to fully elucidate the mechanisms and optimize the application of autologous serum therapy.