Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Defenses Against Pathogens and Herbivores

Defenses Against Pathogens and Herbivores

Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.

Aromatic Compounds: Overview

Aromatic Compounds: Overview

In general, the term ‘aromatic’ indicates a pleasant smell or fragrance from fresh flowers, freshly prepared coffee, etc. In the early history of organic chemistry, many benzene derivatives were isolated from the pleasant odor oils of the plants. For example, vanillin was isolated from the oil of vanilla, methyl salicylate from the oil of wintergreen, and cinnamaldehyde from the oil of cinnamon. They all had a pleasant odor; hence the name aromatic was given.
In 1825, Faraday isolated benzene...

Antifungal Agents

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

Drugs that Stabilize Microtubules

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Curvulinic Acid-Gregatin Hybrids with Anti-inflammatory Activity from a Soil-Derived Fungus <i>Penicillium</i> sp. KYS-21.

Journal of natural products·2026

Same author

19-<i>nor</i>-Clerodane Diterpenoid Dimers from <i>Croton euryphyllus</i> and Their NLRP3 Inflammasome Inhibitory Activity.

Organic letters·2026

Same author

Discovery and Biosynthesis of Lanthipeptides Featuring an Azepinoindole Scaffold by Radical <i>S</i>-Adenosylmethionine Enzyme-Catalyzed C-C Bond Formation.

Journal of the American Chemical Society·2026

Same author

Solid-Phase Synthesis of Orberryamides A-D and Their Derivatives Reveals PPARγ-Mediated Th17 Differentiation Inhibitors.

Organic letters·2026

Same author

Phainanones A-D, Four Aromatic Diterpenoids with Anti-HIV Activity from <i>Phyllanthus hainanensis</i>.

Journal of natural products·2026

Same author

Discovery of spiroindolediketopiperazine alkaloids from Penicillium sp. KYS-32 as dual inhibitors of ABCB1 and ABCG2 to reverse multidrug resistance.

Phytochemistry·2026

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Terpenoids from Toona ciliata.

Hua-Dong Chen¹, Sheng-Ping Yang, Yan Wu

¹State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai, People's Republic of China.

Journal of Natural Products

|March 12, 2009

Summary

Researchers isolated novel norlimonoids, triterpenoids, and diterpenoids from Toona ciliata. One compound, toonaciliatin M, demonstrated moderate antifungal activity against Trichophyton rubrum.

More Related Videos

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Published on: August 16, 2018

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study

Published on: March 8, 2024

Related Experiment Videos

Last Updated: Jun 25, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Published on: August 16, 2018

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study

Published on: March 8, 2024

Area of Science:

Natural Product Chemistry
Phytochemistry
Medicinal Chemistry

Background:

Toona ciliata, a plant species, is a potential source of bioactive natural products.
Previous research has identified various compounds from the Toona genus, highlighting its chemical diversity.

Purpose of the Study:

To isolate and characterize new chemical constituents from the leaves and twigs of Toona ciliata.
To evaluate the antifungal activity of the isolated compounds.

Main Methods:

Extraction and isolation of compounds from Toona ciliata using chromatographic techniques.
Structure elucidation of the isolated compounds based on comprehensive spectroscopic data (e.g., NMR, MS).
Antifungal activity testing using microdilution methods against Trichophyton rubrum.

Main Results:

Isolation of three new norlimonoids (compounds 1-3), two new tirucallane-type triterpenoids (compounds 4-5), and one new pimaradiene-type diterpenoid (compound 6).
Identification of two known limonoids and eight known tirucallane-type triterpenoids.
Toonaciliatin M (compound 6) exhibited moderate antifungal activity against Trichophyton rubrum, with a Minimum Inhibitory Concentration (MIC) of 12.5 microg/mL.

Conclusions:

The study successfully identified novel limonoid, triterpenoid, and diterpenoid compounds from Toona ciliata.
Toonaciliatin M is a promising compound with potential antifungal properties against dermatophytes like Trichophyton rubrum.
Further investigation into the structure-activity relationship and mechanism of action of toonaciliatin M is warranted.