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TRAIL gene therapy: from preclinical development to clinical application
Thomas S Griffith1, Brittany Stokes, Tamara A Kucaba
1Department of Urology, University of Iowa, 375 Newton Road, Iowa City, IA 52242, USA. thomas-griffith@uiowa.edu
Current Gene Therapy
|March 12, 2009
Summary
TNF-related apoptosis-inducing ligand (TRAIL) shows promise as a cancer therapy due to its tumor-specific apoptosis induction. TRAIL gene therapy is being explored to overcome limitations of protein administration for effective antitumor activity.
Area of Science:
- Oncology
- Molecular Biology
- Gene Therapy
Background:
- TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in tumor cells selectively, sparing normal tissues.
- Extensive research covers TRAIL/TRAIL receptor expression, signaling pathways, and modulating tumor cell sensitivity.
- TRAIL's potential as a cancer therapeutic has been investigated since its discovery in 1995.
Purpose of the Study:
- To explore TRAIL gene transfer therapy as an alternative antitumor strategy.
- To address limitations associated with systemic recombinant TRAIL protein administration.
- To translate preclinical findings into clinical applications for treating human primary tumors.
Main Methods:
- Investigating TRAIL gene transfer for localized delivery.
- Analyzing TRAIL/TRAIL receptor expression and signaling.
- Developing methods to enhance tumor cell sensitivity to TRAIL.
Main Results:
- TRAIL gene transfer offers an alternative to recombinant protein therapy.
- Intratumoral TRAIL gene delivery presents challenges for maximal therapeutic potential.
- Preclinical studies are advancing towards clinical translation.
Conclusions:
- TRAIL gene therapy is a promising approach for cancer treatment.
- Further research is needed to optimize TRAIL gene delivery and efficacy.
- Clinical translation aims for robust tumoricidal activity with minimal toxicity.
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