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Updated: Jun 25, 2026

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
Published on: March 14, 2021
Lysophospholipids: their generation, physiological role and detection. Are they important disease markers?
1Universität Leipzig, Medizinische Fakultät, Institut für Medizinische Physik und Biophysik, Härtelstr. 16-18, D-04107 Leipzig, Germany.
Abstract:
The concentration of lysophospholipids (LPL) increases under pathological conditions and, thus, LPL attract diagnostic and pharmacological interest. LPL are particularly interesting because they possess pro- and anti-inflammatory properties and can be generated by phospholipases and reactive oxygen species (ROS). This review provides an overview of the mechanisms by which LPL are generated and how they can be determined. The effects of LPL as signaling molecules and their roles in different pathologies are discussed. The focus will be on lysophosphatidylcholine (LPC).
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