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Screening of SMG7-binding peptides by combination of phage display and docking simulation analysis
Muhammed Zahed1, Toshikazu Suzuki, Akiko Suganami
1Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, Inohana, Chiba 260-8670, Japan.
Abstract:
We screened SMG7-binding peptides with phage display and docking simulation analysis. Although a consensus motif was absent in the phage display-derived candidates, we succeeded to find a peptide CDDRPPKSC, which can bind specifically to SMG7. We conclude that docking simulation helps to find high-affinity peptides efficiently, even if the phage display-screened candidates lack a consensus region.
